It’s Wednesday, and that means it’s time to break out the flex fantasy football rankings for Week 5 of the 2021 NFL season. If you’re new to the concept of flex rankings, these are simply the combined overall rankings for running back, wide receiver, and tight end for each week during the fantasy football season. These are not suggestions for who to start in your flex spots.

This list is our initial rankings, but it will change a lot throughout the week. If you want all of the latest updates, then be sure to check our staff rankings page.

1. Davante Adams @CHI (WR1) – Adams went nuts last week and slides up to the top spot with Derrick Henry facing a tough Bills defense.

2. Derrick Henry vs. BUF (RB1) – The Bills are good in all...

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