| QB | RB | RZB | 3RB | WR 1 | WR 2 | WR 3 | TE | K |
| C.J. Beathard | Jeffery Wilson | Jeffery Wilson | Jeffery Wilson | Brandon Aiyuk | Richie James | Kendrick Bourne | George Kittle | Tristan Vizcaino |
| Jimmy Garoppolo | Kyle Juszczyk | Tevin Coleman | Raheem Mostert | Deebo Samuel | Chris Thompson | Trent Taylor | Jordan Reed | Robbie Gould |
| Nick Mullens | Tevin Coleman | Jerick McKinnon | Tevin Coleman | - | - | Kevin White | Ross Dwelley | - |
| - | Jerick McKinnon | Jamycal Hasty | Jerick McKinnon | - | - | - | Daniel Helm | - |
| - | Jamycal Hasty | Raheem Mostert | Kyle Juszczyk | - | - | - | Charlie Woerner | - |
| - | Raheem Mostert | - | - | - | - | - | - | - |
Rankings
| Player | Brad Evans | Jeff Radcliffe | Consensus |
| Moseley | | | 0 |
ADP Data
| Site | Best Ball | Season Long |
 | | |
 | N/A | |
 | | |
 | N/A | |
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