| QB | RB | RZB | 3RB | WR 1 | WR 2 | WR 3 | TE | K |
| Matthew Stafford | Cam Akers | Cam Akers | Darrell Henderson | Robert Woods | Cooper Kupp | DeSean Jackson | Tyler Higbee | Matt Gay |
| John Wolford | Xavier Jones | Darrell Henderson | - | Van Jefferson | Bennett Skowronek | Jacob Harris | Brycen Hopkins | Sam Sloman |
| Josh Love | Darrell Henderson | - | - | Brandon Polk | Nsimba Webster | Trishton Jackson | Johnny Mundt | - |
| - | Jake Funk | - | - | - | Earnest Edwards | - | - | - |
Rankings
| Player | Brad Evans | Jeff Radcliffe | Consensus |
| Jefferson | | | 0 |
Projection
| Player | Rec Yards | TDs | PPR |
| Jefferson | 180.96 | 0.94 | 37.4 |
ADP Data
| Site | Best Ball | Season Long |
 | 282.21 | 282.21 |
 | N/A | |
 | 245.38 | 260.90 |
 | N/A | 231.08 |
