The Indianapolis Colts take on the Tennessee Titans in an important divisional game to determine who will take the lead in the AFC South. The Colts have one of the best run defenses in the NFL, while the Titans have one of the best running backs in Derrick Henry. Both teams have turned to the air and had exciting games this season, and this game could be another thriller. As a pick 'em with a 48.5-point total and with the game having multiple different directions it could go, it makes it perfect for a DFS showdown slate. 

Injury report

Titans

Out 

S: Dane Cruikshank
WR: Adam Humphries
TE: MyCole Pruitt 
CB: Adoree' Jackson

Colts

Questionable

TE: Mo Alie-Cox (expected to play)

Out

TE: Jack...